Broad reach
Membrane instability is a critical feature across multiple pathologies, including muscular dystrophy, myocardial infarction, and trauma related injuries.
Building a new layer of muscle protection
Elymus is engineering bottlebrush macromolecules designed to stabilize damaged muscle cell membranes, starting with Duchenne muscular dystrophy (DMD).
Preclinical development stageDMD lead indicationPeer-reviewed foundation
Engineering Biology Approach
Protecting the membrane that protects the muscle
In Duchenne muscular dystrophy, loss of dystrophin leaves the sarcolemma vulnerable to mechanical stress and disruption. Elymus is developing a powerful new class of macromolecules, Elymers™, designed to engage and stabilize the muscle membrane.
How the platform worksMechanism overview
Elymer™ proposed mechanism
of action
Hypothesis on action of the macromolecule on the lipid bilayer: patch, repair and heal.
01Patch
Unique performance
Bottlebrush designs have demonstrated differentiated membrane engagement, cellular protection, and physiological outcomes in preclinical studies.
Rigorous science
Discovery and engineering are grounded in molecular characterization and peer-reviewed work from leaders in macromolecular science and muscle biology.
Lead program
Duchenne muscular dystrophy
A devastating genetic disease defined by progressive muscle degeneration and membrane fragility.
Discovery Lead optimization IND-enabling Clinical
Listen
Base by Base · Episode 173